Cannibigerol (CBG) for Glaucoma
What is CBG and what is the endocannibinoid system?
CBG is one of many cannabinoids found in the cannabis plant, often referred to as the "mother cannabinoid" due to its role as a precursor to other cannabinoids like THC and CBD. Unlike THC, CBG is non-psychoactive, meaning it doesn't produce the euphoric "high" associated with cannabis use. Instead, it offers potential therapeutic benefits without the mind-altering effects. Endocannibinoid receptors are found throughout the human body and our bodies produce its own cannibinoids which bind to these receptors.
Endocannabinoids are molecules produced naturally by the human body that interact with the endocannabinoid system (ECS), a complex network of receptors and enzymes involved in regulating various physiological processes. These molecules play crucial roles in maintaining homeostasis, or balance, within the body.
As we age, there is evidence to suggest that the production of endocannabinoids declines. Several factors contribute to this decline:
1. Changes in Metabolism: With age, the body's metabolic processes undergo changes, including alterations in lipid metabolism, which can impact the synthesis and breakdown of endocannabinoids.
2. Decline in Receptor Sensitivity: Endocannabinoids exert their effects by binding to cannabinoid receptors, primarily CB1 and CB2 receptors. Studies have shown that the density and sensitivity of these receptors may decrease with age, leading to diminished responsiveness to endocannabinoids.
3. Dysregulation of Enzymes: Enzymes responsible for synthesizing and degrading endocannabinoids, such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), may become dysregulated with age. This dysregulation can disrupt the balance of endocannabinoid levels in the body.
4. Oxidative Stress and Inflammation: Aging is associated with increased oxidative stress and chronic inflammation, which can negatively impact the ECS. Oxidative stress can impair the function of ECS enzymes, while inflammation may alter endocannabinoid receptor expression and signaling.
Consequences of Reduced Endocannabinoid Levels:
The decline in endocannabinoid production with age may have significant implications for overall health and wellness. Since the ECS plays a vital role in regulating numerous physiological processes, including mood, appetite, pain perception, immune function, and neuroprotection, dysregulation of this system can contribute to age-related conditions and diseases.
CBG can help glaucoma patients manage IOP
Glaucoma is a progressive eye condition characterized by increased intraocular pressure (IOP), which can lead to optic nerve damage and vision loss if left untreated. While traditional treatments such as eye drops and surgeries exist to manage glaucoma, researchers are exploring alternative therapies, including cannabinoids like cannabigerol (CBG) found in cannabis plants. Research suggests that CBG may have ocular hypotensive properties, meaning it could help lower intraocular pressure. A study published in the Journal of Ocular Pharmacology and Therapeutics found that CBG, when applied directly to the eyes of mice, effectively reduced intraocular pressure
My personal experience with CBG
After my diagnosis I was able to purchase a used air-puff tonometer and begin my own characterization of my intraocular pressure (IOP). Over weeks I measured both eyes at various times of the day from waking until bedtime and after certain daily and routine activities. Here were my results:
self-tonometry cbg IOPs vs no cbg iops
My IOP without the use of CBG
Without the use of CBG my IOP would decrease at a slower rate throughout the day with a higher low and many higher highs.
My IOP with the use of CBG
With CBG, as soon as I awaken my IOP drops 7 mm Hg over the the first 15 minutes. This is in line with some studies which feature normal eyes. Note that there are fewer readings above the yellow line (which is the maximum range). Note that the average line is at a lower slope but starts at a much lower reading. This means overall my pressures are lower with the CBG oil.
CBG products
Mellow Pure CBG oil (Canada)
Mellow Pure CBG oil (Canada)
Mellow Pure CBG oil (Canada)
This is the CBG oil I started with and still use today. It is pure CBG isolate in MCT coconut oil. Shake well before each use and place in refrigerator after opening. Mellow publishes their 3rd party lab results on their website and all cannibis producers are regulated by Health Canada.
Mellow Pure CBG oil (USA)
Mellow Pure CBG oil (Canada)
Mellow Pure CBG oil (Canada)
This CBG oil appears to be equivalent to the mellow oil I take in Canada, but it is available in the USA. It is a tincture, and is the same dosage per volume as the one I take.